Statistics

  • Table 1. Demographic and profile statistics of iMETHYL
  • Monocytes CD4+ T cells Neutrophils
    Demographic characteristics of study subjects N 102 102 106

    Males, N

    (%)

    48 (47.1) 49 (48.0) 53 (50.0)

    Median age

    (range)

    62.5 (35–75) 62.0 (35–75) 56.5 (24–81)
    DNAm profiles

    Sequencing

    depth1

    31.1 ± 1.8 31.0 ± 1.6 50.2 ± 12.4

    # of

    autosomal

    CpGs2

    23,941,843 24,037,541 25,395,185
    Gene expression profiles # of 33,917,157 ± 35,175,996 ± 46,667,933 ±

    sequencing

    reads1

    3,153,528 1,275,575 6,691,010
    # of genes3 16,789 18,894 14,547
    SNV profiles # of SNVs4 4,434,123 in preparation

    1Average ± standard deviation

    2CpGs that were retained in ≥ 50% of subjects for each cell type

    3Genes that were expressed with a FPKM ≥ 0.1 in ≥ 50% of subjects for each cell type

    4SNVs with a MAF ≥ 5% and reported in dbSNP138

    Abbreviations: DNAm, DNA methylation; FPKM, fragments per kilobase of exon per million mapped fragments; MAF, minor allele frequency; SNV, single nucleotide variant.



Number of detected CpG sites per chromosome

  • Table2. Number of detected CpG sites per chromosome
  • #. CpGs with call rate >= 50%
    Chr CD4+ T cells Monocytes Neutrophils
    1 2,050,589 2,042,138 2,163,045
    2 1,934,170 1,924,656 2,053,226
    3 1,461,635 1,454,563 1,555,932
    4 1,283,599 1,275,763 1,382,801
    5 1,333,428 1,326,857 1,421,322
    6 1,328,810 1,321,901 1,412,310
    7 1,385,410 1,379,808 1,470,721
    8 1,163,948 1,158,964 1,233,148
    9 1,046,654 1,042,021 1,107,206
    10 1,218,114 1,213,370 1,281,772
    11 1,183,442 1,180,273 1,243,947
    12 1,166,095 1,161,288 1,232,270
    13 710,513 706,827 762,151
    14 779,550 779,219 825,152
    15 769,698 766,454 811,467
    16 990,124 987,665 1,031,776
    17 1,073,533 1,070,104 1,115,459
    18 613,616 610,897 650,326
    19 996,080 994,756 1,030,403
    20 677,115 675,502 701,829
    21 342,081 340,618 360,625
    22 529,337 528,199 548,297
    Autosomal 24,037,541 23,941,843 25,395,185
           
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